About the event
For the first time, Norwich, UK will host two distinguished conferences - Genome 10K 2017; the biannual conference exploring critical topics essential for understanding how complex animal life evolved through changes in DNA and how we can use this to help save dying species; and Genome Science 2017 - an annual meeting exploring advances in genomics technology and computational methodologies as well as innovation in its application.
The growing Genome 10K Community of Scientists (G10KCOS), made up of leading scientists representing major zoos, museums, research centers, and universities around the world, is dedicated to coordinating efforts in a major tissue specimen collection that will lay the groundwork for a large-scale sequencing and analysis project.
The mission of the Genome 10K COS is to assemble a genomic zoo of some 10,000 vertebrate species to help to understand how complex animal life evolved through changes in DNA and use this knowledge to become better stewards of the planet.
The Genome 10K Project was founded by David Haussler, Oliver Ryder, and Stephen O'Brien, who launched the project in April 2009 at a three-day meeting at the University of California, Santa Cruz.
The Genome Science meeting started out life in 2011 as the UK Next Generation Sequencing meeting, hosted by the DeepSeq facility at the University of Nottingham. Since then it has evolved and grown to be a successful event attracting in the region of 250 delegates each year. This meeting represents a fantastic opportunity for both academia and industry to engage, sharing advances, innovations and challenges in working with -omics data.
In addition to a programme packed full of interesting sessions, we have some fantastic invited speakers who will epitomise the prestige and strength of these conferences. There will also be plenty of networking opportunities, such as the social mixer and conference dinner, as well as the poster sessions. We believe training is crucial to the success of all research projects, including the G10K project and its long-term attainment of objectives. Alongside training for early career researchers we will also include parallel Special Interest Group sessions, which will monitor progress in the sector and set new milestones of the G10K project.
Guest Speakers
Prof Kathy Belov
University of Sydney, Australia
Kathy’s research expertise is in the area of comparative genomics and immunogenetics of Australian wildlife.
Talk: Saving the Tasmanian devil from extinction
Prof Peter Holland
University of Oxford, UK
Peter's research interests focus on how the evolution of animal diversity can be explained through evolution of the genome.
Talk: Homeobox genes and animal evolution: from duplication to divergence
Dr Adam M. Phillippy
Computational and Statistics Branch, NHGRI, Maryland, US
Dr. Phillippy is head of the Genome Informatics Section and a tenure-track investigator in the Computational and Statistical Genomics Branch at the National Human Genome Research Institute.
Talk: Towards the gapless assembly of complete vertebrate genomes
Dr Hilary Burton
PHG Foundation, Cambridge, UK
Exploring many dimensions of genomics in healthcare including disease prevention, making a precise diagnosis in rare and more common diseases, choosing drug treatments and assessing reproductive risk.
Talk: Genomics in healthcare: the challenges of complexity
Programme
Day 1 - 29 August 2017
Science Communication Workshop
Watson & Crick
Welcome: Federica Di Palma (Earlham Institute), Tom McCabe (Norfolk County Council), Sally Ann Forsyth (Norwich Research Park)
Main Auditorium
Plenary 1
Main Auditorium
Chair:
Adam Phillipy
Towards the gapless assembly of complete vertebrate genomes
Kathy Belov
Saving the Tasmanian devil from extinction
Coffee Break
Session 1a
Main Auditorium
Vertebrate Genomics
Chair: Federica Di Palma
Session 1b
Watson & Crick
Plant Genomics
Chair: Laura-Jayne Gardiner
Session 1c
Franklin & Wilkins
Microbial Genomics
Chair: Kate Baker
Alex Cagan
Comparative genomics of animal domestication
(Session 1a)
Ksenia Krasileva
Evolution of plant immune receptors
(Session 1b)
John Lees
Scalable pan-genome-wide association studies in bacteria
(Session 1c)
Gaik Tamazian
(01) Comparative whole-genome study of eleven Felidae species from six lineages
(Session 1a)
Andrea Harper
Using Associative Transcriptomics to predict tolerance to ash dieback disease in European ash trees
(Session 1b)
Gemma Langridge
Contaminant or infective agent? Re-classifying the staphylococci for modern medicine
(Session 1c)
Rebecca Jennings
(02) A Cross-Species Bioinformatics and FISH approach to physical mapping of Mammalian Genomes
(Session 1a)
Will Nash
(03) Expansion of gene families and signatures of selection in the Australian marsupials
(Session 1a)
Steve Kelly
(O5) The evolution of photosynthetic efficiency
(Session 1b)
Susanna Salter
(O7) A novel species of human nasopharyngeal bacteria, distantly related to the avian pathogen Ornithobacterium rhinotracheale
(Session 1c)
Neil Gemmell
(04) The tuatara genome project— Unlocking the genome of a living fossil
(Session 1a)
Bernardo Clavijo
(O6) Designing multi-genome graphs for crop genomics and genetics: a wheat-centric view
(Session 1b)
Mark McMullan
(O8) The population genetics of the ash dieback invasion of Europe highlights huge adaptive potential of the causal fungus, Hymenoscyphus fraxineus
(Session 1c)
TBC
Social Mixer
Earlham Institute
Introduction: Sally Ann Forsyth
Day 2 - 30 August 2017
Session 2a
Main Auditorium
Evolutionary Genomics
Chair: Beth Shapiro
Session 2b
Watson & Crick
Clinical and Translational Genomics
Chair: Jonathan Coxhead
Session 2c
Franklin & Wilkins
Agricultural Genomics
Chair: Mick Watson
Emma Teeling
Growing old yet staying young: A genomic perspective on bats’ extraordinary longevity
(Session 2a)
Joris Veltmann
De novo mutations in genetic disease
(Session 2b)
Alan Archibald
Precision engineering for PRRSV resistance in pigs
(Session 2c)
Joel Armstrong
(O9) A reference-free whole-genome alignment of hundreds of mammalian genomes
(Session 2a)
Matthew Hurles
Deciphering Developmental Disorders
(Session 2b)
Nicola Patron
Engineering Plant Genomes for Farming and Pharming
(Session 2c)
Elinor Karlsson
(O10) The 200 Mammals Genome Project: Understanding Evolutionary Conservation at Single Base Resolution
(Session 2a)
Daniel Macqueen
(O11) Whole genome duplication and the evolution of salmonid fish: the state-of the art
(Session 2a)
Vladimir Teif
(O13) Nucleosome positioning as a cell memory in cancer transitions
(Session 2b)
Katrina Morris
(O15) Downregulation of immune genes in quail in response to H5N1 infection
(Session 2c)
Yannick Wurm
(O12) The evolution of social chromosomes in fire ants
(Session 2a)
Weronika Gutowska-Ding
(O14) Good or bad sequencing data? Setting a benchmark for the quality of diagnostic NGS in the lab
(Session 2b)
Gil Ronen
(O16) Pan-genome assembly of population haplotypes provides a comprehensive solution to common obstacles in modern breeding
(Session 2c)
Coffee Break
Session 3a
Main Auditorium
Conservation Genomics
Chair: Emma Teeling
Session 3b
Watson & Crick
Developmental Biology
Chair: Aziz Aboobakar
Session 3c
Franklin & Wilkins
Microbial Communities
Chair: Nick Loman
Beth Shapiro
The genomic consequences of inbreeding in mountain lions, Puma concolor
(Session 3a)
Kristin Tessmar
Genomic and transcriptomic approaches for the study of daily, monthly and seasonal timing
(Session 3b)
Mads Albertsen
Towards a fully populated tree of life
(Session 3c)
Matthew D. Clark
(O17) Conservation genomics of the pink pigeon
(Session 3a)
Andrea Munsterberg
Cellular dynamics and lineage specification in developing somites
(Session 3b)
Lindsay Hall
Early life microbial communities
(Session 3c)
Taras K. Oleksyk
(O18) Novel genome assembly approach contributes to natural history and conservation of the Hispaniolan solenodon, Solenodon paradoxus
(Session 3a)
Katrina Morris
(O19) Characterisation of koala lactation genes using a combined transcriptomic, proteomic and genomic approach
(Session 3a)
Carlos R. Infante
(O21) Enhancers and the convergent evolution of limb reduction in squamates
(Session 3b)
Christopher Quince
(O23) DESMAN: a new tool for De novo Extraction of Strains from MetAgeNomes
(Session 3c)
Antonia Ford
(O20) Genomic approaches to identification and preservation of wild tilapia species and unique genetic resources
(Session 3a)
Dominik Handler
(O22) Using long reads to understand small RNAs
(Session 3b)
Sam Nicholls
(O24) Hansel and Gretel: A fairy tale of recovering haplotypes from metagenomes with a happy ending
(Session 3c)
Posters - Odd Numbers
Session 4a
Main Auditorium
Sequencing Technology and Developments
Chair: Mike Quail
Session 4b
Watson & Crick
Meet the Editors
G10KGS Careers Workshop: Effective CVs for academic and industry research
Dr Rebecca Wyand, Dr Rosemary Bass
13:30 - 14:30 Core Workshop
14:45 - 17:00 1 to 1 Consultations
Slots are as follows:
14:45 - 15:00
15:00 - 15:15
15:15 - 15:30
Break
15:45 - 16:00
16:00 - 16:15
16:15 - 16:30
16:30 - 16:45
16:45 - 17:00
You can sign up for an individual consultation at the Conference Reception.
Aaron McKenna
Information and storage recovery using the diversity of second-generation sequencing technologies
(Session 4a)
Gigascience
Laurie Goodman and Scott Edmunds
Genome Biology
Andrew Cosgrove
Nature
TBC
PLoS
TBC
(Session 4b)
Deanna Church
(O25) Linked-Reads enable efficient de novo, diploid assembly
(Session 4a)
Science
TBC
(Session 4b)
Rebecca O'Connor
(O26) Novel approach to chromosome-level mapping of avian genomes doubles the number of assemblies
(Session 4a)
Iliana Bista
(O27) Scaling up the generation of reference quality genomes across a range of vertebrate diversity
(Session 4a)
Ian Fiddes
(O28) Comparative Annotation Toolkit (CAT) - simultaneous annotation of related genomes using a high quality reference
(Session 4a)
Lesley Shirley
(O29) High Throughput Genomics Enabled by NEBNext Ultra II FS
(Session 4a)
Coffee Break
Session 5a
Main Auditorium
Genome Informatics
Chair: Rob Davey
Session 5b
Watson & Crick
Meet the Editors (cont.)
Doreen Ware
TBC
(Session 5a)
Colin Dewey
(O30) Genome-wide characterization of RNA processing event dependencies
(Session 5a)
Daniel Mapleson
(O31) Sequence alignment using optical correlation
(Session 5a)
John Davey
(O32) Chromosome assemblies with Oxford Nanopore sequencing
(Session 5a)
William Chow
(O33) gEVAL, a web-based browser to help you evaluate and assess the state of your assembly
(Session 5a)
Jonas Korlach
(O34) Full-length Transcript (Iso-Seq) Profiling for Improved Genome Annotations
(Session 5a)
Conference Dinner
The Halls
Day 3 - 31 August 2017
Session 6a
Main Auditorium
Population Genomics
Chair: Wilfried Haerty
Session 6b
Watson & Crick
Sponsors Showcase
Chair: Darren Heavens
Richard Durbin
Whole genome sequence studies of the Lake Malawi cichlid adaptive radiation
(Session 6a)
Sarah Cossey (EI) and Spencer Lamb (Verne Global)
Why Icelandic HPC is Bioinformatics’ best friend
(Session 6b)
Adam Peltan (NEB)
NEBNext®: Optimised Workflows for NGS Library Preparation
(Session 6b)
Gemma Murray
(O35) Natural selection shaped the rise and fall of passenger pigeon genomic diversity
(Session 6a)
Gaurav Kaul (Intel)
AI + Precision Medicine + Moore’s Law = The 21st Century virtuous cycle
(Session 6b)
Kai Zeng
(O36) Determinants of the efficacy of natural selection on coding and noncoding variability in two passerine species
(Session 6a)
Klaus Hentrich (TTPLabtech)
Automated low-volume liquid handling for cost-effective NGS library preparation and single cell genomics
(Session 6b)
Alicia C. Bertolotti
(O37) Copy number variation in the Atlantic salmon (Salmo salar) genome
(Session 6a)
Deanna Church (10x Genomics)
The Chromium System for Enabling High Resolution Biology
(Session 6b)
Maribet Gamboa
(O38) Genome-wide signatures of local adaptation in SNP loci and proteins of stonefly populations along a latitudinal gradient in Japan
(Session 6a)
Kay Körner (Eppendorf)
Yield, Specificity and Inhibition of PCR: how to get better results!
(Session 6b)
Coffee Break
Session 7a
Main Auditorium
Single-Cell
Chair: Iain Macaulay
Session 7b
Watson & Crick
Sponsors Showcase
Chair: Chris Watkins
Muzlifah Haniffa
Deconstructing the immune system using single cell technologies
(Session 7a)
Mark Mooney (DNAnexus)
Creating Community in the Cloud
(Session 7b)
Thomas Keane (EMBL-EBI rep BioNano)
Acomys genome project: A comparative genomic framework for evolutionary and biomedical studies
(Session 7b)
Tamir Chandra
Understanding cellular heterogeneity in cellular senescence and ageing through single cell transcriptomics
(Session 7a)
Brad Hehli (Perkin Elmer)
A Comparison of 16S Amplicons in Microbial Community Standards & Environmental Samples
(Session 7b)
Michelle Vierra (PacBio)
PacBio SMRT Sequencing on the Sequel System: higher throughput, lower cost, better science
(Session 7b)
Stephen Sansom
Transcript structures in the thymus: improvised or rehearsed?
(Session 7a)
Cindy Lawley (Illumina)
Sequencing and Array-based methods for resolving genomic inquiry
(Session 7b)
Posters - Even Numbers
Plenary 2
Main Auditorium
Chair: TBC
Peter Holland
Homeobox genes and animal evolution: from duplication to divergence
Hilary Burton
Genomics in healthcare: the challenges of complexity
Close of Conference
Coffee Break
Working Group 1
Introductions, mission and refining selection of ordinal level species
Chair: Erich Jarvis
15:30-15:55
Introductions, mission, and species selection rationale
Erich Jarvis, Rockefeller University, NY, USA; Steve O’Brien, St. Petersburg State University, Russia
15:55-16:10
Tissue and permit requirements for near chromosomal level assemblies
Olivier Fredrigo, Rockefeller University, NY, USA
16:10-16:40
Breakout groups for refining draft ordinal species list
(Integration with B10K, Bat1K and 200 mammal projects)
Mammal leads: Oliver Ryder, Warren Johnson, Emma Teeling, Federica Di-Palma, Elinor Karlsson, Harris Lewin (Harris in absentia)
Bird leads: Erich Jarvis, Guojie Zhang (in absentia), Tom Gilbert (in absentia)
Fish leads: Byrappa Venkatesh, Richard Durbin
Amphibian leads: Andrew Crawford (Skype in and represented by Kathryn Elmer)
Reptile leads: Robert Murphy
16:40-17:00
Group discussion to finalize ordinal species list
Training
Career Development
Darwin Training Room, EI
Laurie Goodman (GigaScience)
Andrew Cosgrove (Genome Biology)
Working Group 2
Settling on assembly approach for ordinal level species
Chair: Adam Phillippy
9:00–9:15
Proposed approach going forward for near gapless, chromosomal level, and phased assemblies
Adam Phillippy, NIH, Bethesda MD, USA
9:15–9:30
Proposed alternatives for long-range scaffolding
Richard Durbin, Sanger Institute and Cambridge University, UK
9:30–9:45
Proposed path towards near perfect G10K assemblies
Gene Myers, Max Planck Institute, Dresden, Germany
9:45–10:00
200 mammal family project: Short read alternatives and G10K criteria
Elinor Karlsson, Broad MIT, USA; Federica Di-Palma, Earlham, UK
10:00–10:30
Group discussion to finalize assembly approach for ordinal project
Training
De novo assembly
25 places
Darwin Training Room, El
Training
Differential Expression Analysis and Visualisation using Galaxy
25 places
Chris Lamb Training Suite
Coffee Break
Working Group 3
Settling on annotation approach for ordinal level species
Chair: Paul Flicek
10:45-11:05
Proposed Ensembl annotation pipeline and requirements for VGP reference chromosomal level, diploid genomes
Fergal Martin and Paul Flicek, EMBL-EBI, Hinxton, UK
11:05-11:25
Proposed NCBI annotation pipeline and requirements for VGP reference chromosomal level, diploid genomes
Francoise Thibaud-Nissen and Kim Pruit, NCBI, Washington DC, USA
11:25-11:50
Proposed UCSC alignment and annotation approach for ordinal level diploid genomes: lessons from the 200 mammals project
Ian Fiddes, Joel Armstrong, and Benedict Paten, UCSC, Santa Cruz, USA
11:50-12:30
Group discussion to finalize requirements and paths for annotations
Lunch
Working Group 4
Deciding on projects to be conducted with ordinal level species
Chair: Erich Jarvis
12:30-12:45
Get food and settle at tables
12:45-13:10
Suggested major VGP projects, publications, and proposed mechanism of credit with ordinal level genomes
Erich Jarvis, Rockefeller University, NY, USA
13:10-13:30
Species and trait database for ordinal level and beyond
Klaus-Peter Koepfli, Smithsonian Conservation Unit, D.C. USA
13:30-14:00
Group discussion to generate list of proposed projects
Coffee Break
Working Group 5
Raising remaining funds for ordinal level species
Chair: Beth Shapiro
14:30-14:45
Crowd funding among scientists, outreach, and donation website for genomes
Sadye Paez, Rockefeller University, NY, USA
14:45-15:00
Proposed plans for foundation and other funding
Beth Shapiro, UCSC, Santa Cruz, USA
15:00-15:30
Group discussion on plans for raising funds
Coffee Break
Working Group 6
Settling on person roles, finalizing species list, and plans for coming year
Chair: Erich Jarvis
15:45-16:00
Summary of workshop outcomes
Erich Jarvis, Rockefeller University, NY, USA
16:00-17:00
Finalizing agreements to species list, genome assembly, annotations, projects, funding, timeline, and person roles
17:00
Close of G10K-VGP workshop
Closed-door G10K council business meeting
Register today.
Registration deadline: 31 July 2017