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Life at Earlham Institute
We believe that our people are our greatest asset, and we want you to have the freedom to achieve your very best work here.
Every nucleated cell has the potential to identify us. We shed cells wherever we go and different types of contact result in the transfer and mixture of different cell types.
Conventional forensic DNA recovery loses information about the molecule - or cell - the DNA originated from. This information could be critical in mixed samples and establishing where a DNA molecule came from, when it was transferred, and by whom.
Based in the Macaulay Group, this project will combine advances in single-cell isolation, phenotyping, and sequencing with established and novel approaches for human identification from individual cells. Using advanced cell sorting, laser capture microdissection and microfluidic approaches, the student will develop and apply methods for human identification from individual cells.
The student will apply short-tandem repeat (STR)-based analysis methods to single cells. The project will focus on method development with translational potential for the justice system but collaboration with the Nieduszynski group will also explore STR heterogeneity in normal human biology.
We offer a highly collaborative research environment, exceptionally well equipped for single-cell genomics. The project offers experience in highly sought after skills in cell biology, genomics and technology development. The student will be mentored to pursue independent lines of research and gain visibility in the wider research community.
The project has collaborative links with researchers and practitioners in UK forensic science who will provide guidance on technical developments and their applicability in real-world forensic settings.
Further reading:
Huffman K, Ballantyne J. Single cell genomics applications in forensic science: Current state and future directions, iScience. 2023 Nov 17; 26(11): 107961.
Watkins, D.R.L., Myers, D., Xavier, H.E. et al. Revisiting single cell analysis in forensic science. Sci Rep 11, 7054 (2021). https://doi.org/10.1038/s41598-021-86271-6
Application information:
- Apply by 23.59 on Monday 25 November 2024.
- Visit the NRPDTP website for further information on eligibility, funding and how to apply: https://biodtp.norwichresearchpark.ac.uk/
- You can also visit: https://www.earlham.ac.uk/application-guidance
