Life at Earlham Institute
We believe that our people are our greatest asset, and we want you to have the freedom to achieve your very best work here.
Applications are invited for a Postdoctoral Research Scientist to join the Laboratory of Dr Wilfried Haerty in the Research Faculty of the Earlham Institute, based in Norwich, UK.
Background:
During the lifetime of an organism individual cells will acquire both programmed and spontaneous mutations. Most studies have so far focused on the implications of those events in diseases such as cancer, however such events also occur during normal development and can be part of the response to environmental stress or adaptation. The rapid development of single cell approaches now enable the characterisation of the functional implications of cellular heterogeneity.
As part of the Institute Strategic Programme Cellular Genomics, a highly collaborative project bringing together molecular biologists, computational biologists, and computer scientists, we are seeking an enthusiastic and ambitious Postdoctoral Research Scientist to undertake computational analysis of the functional implications of cellular heterogeneity in systems such as mouse and human cell lines.
The role:
The successful candidate will investigate the implication of ploidy variation on gene and transcript expression during cellular differentiation in both in-vitro and in-vivo models through the analysis of short and long read sequencing single cell data. To achieve this, the candidate will develop computational pipelines to reproducibly handle both publicly and newly produced single cell data (genome, transcriptome, epigenome) to enable their integrations and interpretation.
The project is led by Dr Wilfried Haerty, and the successful candidate will work closely with groups across EI (Dr Iain Macaulay, Dr Edyta Wojtowicz, Dr Conrad Nieduszynski) and with external collaborators.
At EI, the post holder will have access to cutting-edge high performance computing facilities and expertise. They will join an active community of experimental and computational biologists working on a wide range of cellular genomics and single-cell analyses. They will have the opportunity to contribute to other projects and the overall development and implementation of single-cell genomic approaches at EI.
The ideal candidate:
The successful applicant will have a PhD in bioinformatics, computational genomics or a related subject. They will have significant experience working with genomic/epigenomic/transcriptomic data, and experience with single-cell genomics analysis.
The candidate should have a demonstrable working knowledge of programming languages such as Python, Perl, or R. it is advantageous if the post holder has experience with long read sequencing.
Additional information:
Salary on appointment will be within the range £36,720 to £39,750 per annum depending on qualifications and experience. This is a full-time post for a contract of 24 months.
This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. Please contact the Human Resources Team if you have any questions regarding your application or visa options.
As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.
The closing date for applications will be 29 November 2024.
