Single-cell sequencing at Earlham Institute
Developing and applying new technology to decode life at single-cell level.
Biography
Dr Iain Macaulay is a Group Leader in Technical Development at the Earlham Institute.
The Group’s research focus is on the development and application of new approaches for integrated sequencing or “multi-omics” of single cells and low-input genome samples.
Such tools allow genetic, epigenetic and transcriptional heterogeneity in diverse biological systems – including bacteria, plants, and animals – to be investigated at cellular resolution.
Projects
Publications
Related reading.
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22 January 2021
Technology
FEATURE
| 8 min READ
5 ways single-cell genomics can transform our understanding of biology
Single-cell sequencing is increasingly becoming an essential part of the biologists’ toolkit.
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27 November 2019
Science
FEATURE
| 8 min READ
Women in Science: Single-Cell Genomics - career choices, equality and ambition (part 1)
We ask what are the most challenging and rewarding aspects of their careers so far, where we're at with gender equality, and what they'd share with those coming up the single-cell ladder.
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03 December 2019
Science
FEATURE
| 8 min READ
Women in Science: Single-Cell Genomics - career choices, equality and ambition (part 2)
We ask what are the most challenging and rewarding aspects of their careers so far, where we're at with gender equality, and what they'd share with those coming up the single-cell ladder.
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19 September 2016
Science
FEATURE
| 5 min READ
Single-cell genomics: what’s in a cell?
The new genomics weapon in the armoury of biologists is ready for action - to seek out the true complexity and diversity of living things. Following his talk at the 'Festival of Genomics' in Boston, Dr Iain Macaulay explains why single-cell genomics is making life scientists stand to attention.
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19 February 2021
Science
FEATURE
| 15 min READ
Pollinating the future of single-cell genomics and crop breeding
With a wealth of experience in genomics and plant biology, Ashleigh Lister is applying her expertise to single-cell genomics - pioneering detailed analysis of pollen grains that can give an unprecedented boost to crop breeders.
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22 September 2021
Science
Technology
FEATURE
| 8 min READ
The blood boneyard: determining the fate of blood stem cells
When student Anita Scoones was considering her research career, she probably imagined using microscopes more than kitchen utensils. But to understand blood cells, you have to start with the bones.
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03 February 2021
Science
FEATURE
| 15 min READ
The story of ageing, told by a single blood cell
Dr Laura Mincarelli works at the cutting edge of single-cell technology, isolating individual blood stem and progenitor cells to understand how we age. What she discovers could one day help us to prevent ageing. In the short term, she is helping to transform our understanding of biology - one cell at a time.
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27 September 2019
Science
FEATURE
| 5 min READ
Exciting developments in single cell genomics
Are you ready for Norwich’s third single cell symposium? Join us at EI - the heart of where single cell technologies and cutting edge genomics pipelines come together. It will be awesome.
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06 August 2021
Science
FEATURE
| 15 min READ
How single-cell genomics can foil drug-resistant cancer
PhD student Silvia Ogbeide explains how she’s using the latest single-cell sequencing technologies to track drug resistance in cancer.